Symbol Name ID |
Nf1
neurofibromin 1 MGI:97306 |
Darker colors indicate more annotations |
Human Phenotypes | Prolonged bleeding time |
Leukemia |
Acute myeloid leukemia |
Chronic myelogenous leukemia |
Juvenile myelomonocytic leukemia |
Disease(s) Associated with NF1 | |||||
acute myeloid leukemia | |||||
juvenile myelomonocytic leukemia | |||||
neurofibromatosis 1 | |||||
neurofibromatosis-Noonan syndrome |
Mouse Phenotypes | increased mast cell degranulation |
enlarged spleen |
abnormal definitive hematopoiesis |
abnormal common myeloid progenitor cell morphology |
abnormal myelopoiesis |
abnormal bone marrow cell morphology/development |
increased neutrophil cell number |
increased granulocyte number |
abnormal hematopoietic cell number |
increased lymphocyte cell number |
increased osteoclast cell number |
increased monocyte cell number |
increased leukocyte cell number |
abnormal microglial cell morphology |
abnormal myeloid leukocyte morphology |
abnormal spleen morphology |
absent spleen germinal center |
spleen fibrosis |
abnormal mast cell physiology |
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Availability | Mouse Genotype | |||||||||||||||||||
Nf1tm1Tyj/Nf1+ | ||||||||||||||||||||
Nf1tm1Par/Nf1tm1Par Tg(Prrx1-cre)1Cjt/0 (conditional) |
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Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn/0 (conditional) |
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Nf1tm1Fcr/Nf1tm1Par Tg(Tek-cre)1Ywa/0 (conditional) |
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Nf1tm1Par/Nf1tm1Fcr Tg(GFAP-cre)#Gtm/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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